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2 edition of Sensitivity analysis for application of the Inhalation Exposure Methodology (IEM) to studies of hazardous waste management facilities found in the catalog.

Sensitivity analysis for application of the Inhalation Exposure Methodology (IEM) to studies of hazardous waste management facilities

F. R O"Donnell

Sensitivity analysis for application of the Inhalation Exposure Methodology (IEM) to studies of hazardous waste management facilities

by F. R O"Donnell

  • 259 Want to read
  • 34 Currently reading

Published by U.S. Environmental Protection Agency, Hazardous Waste Engineering Research Laboratory in Cincinnati, OH .
Written in English

    Subjects:
  • Hazardous waste treatment facilities,
  • Air -- Pollution -- Simulation methods -- Data processing

  • Edition Notes

    StatementF.R. O"Donnell and C.C. Gilmore
    ContributionsGilmore, C. C, Hazardous Waste Engineering Research Laboratory
    The Physical Object
    Pagination2 p. ;
    ID Numbers
    Open LibraryOL14652481M

    Modelling the exposure to chemicals for risk assessment: A comprehensive library of multimedia and PBPK models for integration, prediction, uncertainty and sensitivity analysis - the MERLIN-Expo tool.   Inhalation Exposure Systems: Design, Methods and Operation A batch of the exposure atmosphere is sampled and held in a storage system for later analysis. A sample of the exposure atmosphere can be drawn through an impinger or bubbler at a known flow rate for a certain period of time. and may not replicate the same distribution by Cited by:

    Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry (PDF) ( pp, 5 MB, October , F) Contact Us to ask a question, provide feedback, or report a problem. In a time-dependent sensitivity analysis, different parameters showed different impacts on 1-BP chamber concentration at different exposure times (Supplementary Figure 1). For example, BW and QPC had the maximum effects on the chamber concentration within 1–2 h at 70 ppm, and then reduced their effects with increasing impact of QCC and PB Cited by: 4.

    Hartings J and Roy C () The automated bioaerosol exposure system: Preclinical platform development and a respiratory dosimetry application with nonhuman primates, Journal of Pharmacological and Toxicological Methods, /, , (), Online publication date: 1-JanCited by: The percentile selected to represent the exposure criteria, i.e., 90th, 95th, 99th and the level of significance in determining contamination at a site, i.e., 1% vs 5%, may impact the final assessment. An analysis of the sensitivity of the final assessment to the selection of .


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Sensitivity analysis for application of the Inhalation Exposure Methodology (IEM) to studies of hazardous waste management facilities by F. R O"Donnell Download PDF EPUB FB2

This report discusses the sensitivity of predictions made by the Inhalation Exposure Methodology (IEM) to the more Important, user- controlled input parameters and modeling options that are applicable to low-level emission sources found at hazardous waste management facilities.

United States Environmental Protection Agency Hazardous Waste Engineering Research Laboratory Cincinnati OH * Research and Development EPA//S/ Nov. Project Summary Sensitivity Analysis for Application of the Inhalation Exposure Methodology (IEM) to Studies of Hazardous Waste Management Facilities F.

O'Donnell and C. Gilmore This study investigated the uncer- tainties associated with using the Inhalation Exposure Methodology. On the contrary, whole-body inhalation chamber system is a natural respiratory exposure method and is suitable for evaluating the effect of inhaled particle on both upper and lower respiratory.

characterization methodology are only briefly men-tioned. The organization is by mode of exposure, including immersion of whole animals in chambers, exposures of the head only, exposures of the nose or mouthonly, lungonly, andpartial lungexposures.

Each of these modes of exposure has its own advantages, disadvantages, areas ofapplication. An approach for evaluation of selected sensitivity analysis methods is discussed.

Results from application of the selected sensitivity analysis methods to the testbed model are presented and by: The methods evaluated include the Pearson and Spearman correlation, sample and rank regression, analysis of variance, Fourier amplitude sensitivity test (FAST), and Sobol's method.

As the sensitivity analysis result for workers’ exposure shows (Fig. 1b), in the normal activity range for the workers ( m ≤ x ≤ 2 m), H is the factor that most affects the TTHM concentration in air, accounting for % of the total variance; z has a negative correlation with the exposure concentration and accounts for % of the Cited by: A revised method for assessing acute inhalation toxicity in quantitative risk analysis R.J.

Hansler, scientific researcher, RIVM National Institute for Public Health and the Environment, P.O. Box 1, BA Bilthoven, The Netherlands G.

Stam, scientific researcher, RIVM National Institute for Public Health and the Environment, P.O. Box 1, BA. METHODOLOGY FOR THE ASSESSMENT OF DOSE FROM EXTERNAL EXPOSURE AND INHALATION OF RADIOACTIVE MATERIAL. UNSCEAR Report, Annex A, Levels and effects of radiation exposure due to the nuclear accident after the great east-Japan earthquake and tsunami, Appendix C (Assessment of doses to the public) ContentFile Size: KB.

Occupational inhalation exposure and systemic inhalation absorption 1. Introduction It is explicitly noted here that the purpose of this fact sheet is to summarise previously developed concepts for the assessment of (i) inhalation exposure and (ii) inhalation absorption of metals and metal compounds under occupational exposure situations.

Sensitivity analysis for application of the Inhalation Exposure Methodology (IEM) to studies of hazardous waste management facilities Author: F R O'Donnell ; C C Gilmore ; Hazardous Waste Engineering Research Laboratory.

A new method for sensitivity analysis (SA) of model output is introduced. It is based on the Fourier amplitude sensitivity test (FAST) and allows the computation of the total contribution of each. Table 2 The mean (standard deviation), median and mode of log hazard ratio estimates for fruit and vegetables (FV) intake and number of cigarettes smoked adjusted for the bias with the multivariate method in the sensitivity analysis by varying magnitudes of validity coefficients assumed for the DQs for FV intake \(\left({\rho}_{T_1{Q}_1}\right Author: George O.

Agogo, George O. Agogo, Hilko van der Voet, Pieter van ’t Veer, Pietro Ferrari, David C. Project Management Risk Sensitivity Analysis [28] As an application of the method, this paper demonstrates the risk management system for the large project execution stage now being used at. In order to study the toxicity of such materials, a special technology relating to inhalation exposure systems has evolved.

The purpose of this paper is to provide a description of the techniques which are used in exposing laboratory subjects to airborne particles and by: Exposure assessment showed modeled and measured concentrations are statistically linearly correlated for all VOCs (P exposure using time-weighted model can provide reasonable estimate of personal inhalation exposure to VOCs.

Indoor smoking and recent renovation were identified as two Cited by: The sensitivity analysis showed that several input parameters had major influence on the modeled PAH inhalation exposure and the rankings of different interventions.

The ranking was reasonably robust for the remaining majority of by: Inhalation Exposure Systems: Design, Methods and Operation BRIAN A. WONG CIIT Centers for Health Research, Research Triangle Park, NCUSA ABSTRACT The respiratory system, the major route for entry of oxygen into the body, provides entry for external compounds, including pharmaceutic and toxic materials.

Global sensitivity analysis (SA) was used during the development phase of a binary chemical physiologically based pharmacokinetic (PBPK) model used for the analysis of m-xylene and ethanol co-exposure in by: 3.

monitoring of exposure or for determining compliance with regulatory standards. If this is the goal, the reader should consult other references such as Hawkins (91) and Patty (81), etc. Types of Occupational Exposure Monitoring Data Monitoring data usually consist of area samples, personal inhalation samp les or dermal samples.

Moreover, the most influential factors are quite different for workers’ exposure and public exposure. The 2-D Monte Carlo risk analysis result for the workers indicated that the lowest-risk, highest-risk and two critical points for irrigation height are m, m, m and m when the mean value of the risk is selected as the Cited by: Risk assessment of population inhalation exposure to volatile organic compounds and carbonyls in urban China Uncertainty and sensitivity analysis.

-weighted averages for 24 h or even several weeks while active and canister sampling is more suitable for short-term exposure.

Also, canister methodology is applicable to polar and Cited by:   Modeling of inhalation exposure and risks resulting from exposure to mobile source air toxics can be used to evaluate impacts of reductions from control programs on overall risk, as well as Cited by: